Elizabeth L Hartland Selected Research

Type III Secretion Systems

1/2021	Measuring Effector-Mediated Modulation of Inflammatory Responses to Infection with Enteropathogenic and Shiga Toxin-Producing E. coli.
1/2020	The Salmonella Effector SseK3 Targets Small Rab GTPases.
1/2017	Distinct Roles of the Antiapoptotic Effectors NleB and NleF from Enteropathogenic Escherichia coli.
1/2017	EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.
1/2016	Identification of a Distinct Substrate-binding Domain in the Bacterial Cysteine Methyltransferase Effectors NleE and OspZ.
12/2015	Substrate recognition by the zinc metalloprotease effector NleC from enteropathogenic Escherichia coli.
11/2014	The type III secretion effector NleF of enteropathogenic Escherichia coli activates NF-κB early during infection.
8/2014	The Inflammatory Response during Enterohemorrhagic Escherichia coli Infection.
9/2013	A type III effector antagonizes death receptor signalling during bacterial gut infection.
6/2013	Characterization of the ospZ promoter in Shigella flexneri and its regulation by VirB and H-NS.

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Elizabeth L Hartland Research Topics

Disease

38	Infections 01/2021 - 09/2007
6	Inflammation (Inflammations) 02/2017 - 04/2014
4	Legionnaires' Disease (Legionnaire's Disease) 01/2020 - 01/2012
4	Bacterial Infections (Bacterial Infection) 12/2017 - 06/2013
2	Salmonella Infections (Salmonellosis) 01/2020 - 01/2019
2	Pneumonia (Pneumonitis) 02/2016 - 01/2013
1	Chronic recurrent multifocal osteomyelitis 01/2020
1	Bone Diseases (Bone Disease) 01/2020
1	Weight Loss (Weight Reduction) 01/2019
1	Necrosis 01/2017
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 03/2015
1	Leukemia 02/2015
1	Virus Diseases (Viral Diseases) 02/2015
1	Hemolytic-Uremic Syndrome 08/2014
1	Persistent Infection 06/2010
1	Achlorhydria (Hypochlorhydria) 02/2008

Drug/Important Bio-Agent (IBA)

20	Proteins (Proteins, Gene)FDA Link 01/2021 - 09/2007
11	Type III Secretion SystemsIBA 01/2021 - 04/2011
5	Death Domain ReceptorsIBA 01/2020 - 09/2013
5	CytokinesIBA 01/2020 - 07/2014
4	Type IV Secretion SystemsIBA 02/2016 - 02/2010
3	Arginine (L-Arginine)FDA Link 01/2021 - 10/2017
3	Shiga Toxin (Shigella Toxin)IBA 01/2021 - 08/2014
3	Phosphotransferases (Kinase)IBA 01/2017 - 01/2008
3	Interleukin-8 (Interleukin 8)IBA 01/2016 - 04/2011
2	rab GTP-Binding ProteinsIBA 01/2020 - 08/2014
2	GlycopeptidesIBA 01/2019 - 10/2017
2	Virulence Factors (Pathogenicity Factors)IBA 01/2019 - 05/2010
2	Cysteine Proteases (Cysteine Protease)IBA 02/2017 - 01/2017
2	Caspase 8 (Caspase-8)IBA 01/2016 - 11/2014
2	AntigensIBA 02/2015 - 10/2008
1	HexosesIBA 01/2021
1	AcetylglucosamineIBA 01/2020
1	UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferaseIBA 01/2020
1	Monomeric GTP-Binding ProteinsIBA 01/2020
1	AerosolsIBA 01/2020
1	Syk KinaseIBA 01/2020
1	Interleukin-1 (Interleukin 1)IBA 01/2020
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2020
1	SirtuinsIBA 01/2020
1	Messenger RNA (mRNA)IBA 01/2019
1	Poly I-CIBA 01/2017
1	LipopolysaccharidesIBA 01/2017
1	CaspasesIBA 01/2017
1	SphingosineIBA 02/2016
1	Alanine (L-Alanine)FDA Link 01/2016
1	Amino Acids FDA Link 01/2016
1	Antiviral Agents (Antivirals)IBA 02/2015
1	Toll-Like Receptors (Toll-Like Receptor)IBA 02/2015
1	LigandsIBA 02/2015
1	Interleukin-18 (Interleukin 18)IBA 02/2015
1	Tyrosine (L-Tyrosine)FDA Link 12/2014
1	Complement System Proteins (Complement)IBA 12/2014
1	Caspase 9IBA 11/2014
1	Ligases (Synthetase)IBA 08/2014
1	Biotin (Vitamin H)FDA Link 08/2014
1	His-His-His-His-His-His ((His)6)IBA 08/2014
1	Genetic Markers (Genetic Marker)IBA 08/2014
1	Immunologic Factors (Immunomodulators)IBA 08/2014
1	TOR Serine-Threonine KinasesIBA 07/2014
1	Type I Tumor Necrosis Factor ReceptorsIBA 08/2013
1	FlagellinIBA 07/2013
1	InflammasomesIBA 01/2013
1	Carrier Proteins (Binding Protein)IBA 01/2012
1	Peptide Hydrolases (Proteases)FDA Link 04/2011
1	Protein SIBA 03/2011
1	Anti-Bacterial Agents (Antibiotics)IBA 06/2010
1	Linezolid (Zyvox)FDA Link 06/2010
1	EnzymesIBA 12/2008
1	purineIBA 12/2008
1	AcidsIBA 02/2008
1	VaccinesIBA 02/2008
1	AntacidsIBA 02/2008
1	NF-kappa B (NF-kB)IBA 01/2008
1	chenodeoxycholate sulfate conjugate (CDCS)IBA 09/2007

Therapy/Procedure

5	Therapeutics 02/2016 - 02/2008
1	Euthanasia (Mercy Killing) 01/2019